The effect of ellagic acid on the thrombin-induced hemorrhagic syndrome in the rat.

B,, E. E. CLIFFTON, A. GIROLAMI AND D. AG05TIN0 E LLAGIC ACID has beemi shown to cause a hypercoagulable state in several amiimiial species, presumably by activation of Hageman factor ( factor) XII).”2 In the course of experiments with this compound in dogs, rabbits, and cats, a decrease in oozing from venipuncture sites and raw surfaces was noted.2 A significant decrease in bleeding from the amputated tail of the normal rat ‘as also slio ,,i:s The intraperitoneal or intravenous administration of thrombin causes a bleeding syndrome in the rat amid in the dog.4” This hemorrhagic condition is associated with a reduced level of fibrinogen ( factor I ), proaccelerin ( factor \7) and antihemophilic globulin (factor VIII).46 A mild to moderate decrease iii prothromhin ( factor II ) has also been reported.4’5’7 In the dog increased